Taurine release in developing mouse hippocampus is modulated by glutathione and glutathione derivatives
نویسندگان
چکیده
منابع مشابه
AtOPT6 transports glutathione derivatives and is induced by primisulfuron.
The oligopeptide transporter (OPT) family contains nine members in Arabidopsis. While there is some evidence that AtOPTs mediate the uptake of tetra- and pentapeptides, OPT homologs in rice (Oryza sativa; OsGT1) and Indian mustard (Brassica juncea; BjGT1) have been described as transporters of glutathione derivatives. This study investigates the possibility that two members of the AtOPT family,...
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The aim of the present work was to investigate a new mechanism likely contributing to the toxic action of acetaminophen, especially to explore the possible inhibition of glutathione reductase through an acetaminophen-glutathione conjugate (APAP-SG). APAP-SG conjugate was synthesized by organic synthesis and purified by column chromatography. The inhibitory effect of the conjugate on two types o...
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Although glutathione has been much studied, its oxidation products have not been adequately characterized. The first product of oxidation, the disulphide, GSSG, is a familiar compound, although it is doubtful whether it has been obtained pure. The kinetics of the reaction of GSSG with silver salts have been investigated (Cecil, 1950; Cecil & McPhee, 1957), but the product, the sulphinic acid, G...
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Our understanding of the intrinsic effects of cystic fibrosis (CF) transmembrane conductance regulator (cftr) deletion on resident neonatal alveolar macrophage (AM) remains limited. We previously demonstrated that diminished glutathione (GSH) or excessive AM transforming growth factor beta one (TGFβ1) contributes to AM dysfunction in a variety of disease states. In this study, using a gut-corre...
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Three major forms of cytosolic glutathione S-transferase (designated F1, F2, and F3 transferases according to increasing isoelectric points) were purified to homogeneity from liver of DBA/2J mice, primarily by CM-cellulose and hydroxylapatite chromatography. The purified enzymes were shown to have specific activities of 104, 281, and 143 units/mg, respectively, when assayed with 1 m~ each of l-...
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ژورنال
عنوان ژورنال: Amino Acids
سال: 2007
ISSN: 0939-4451,1438-2199
DOI: 10.1007/s00726-007-0587-z